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Updated: Jun 11, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
High-efficiency detection of primary amine-based chiral molecules by a facile aldimine condensation reaction
Yang Yu1, Aiyan Shi2, Tongtong Wang1
1College of Advanced Materials Engineering, Jiaxing Nanhu University 314001 Jiaxing P. R. China yuyang@jxnhu.edu.cn.
Abstract:
Detection of chiral molecules in a high-efficiency way is very important to meet the demands for chiral analysis in drug testing, asymmetric synthesis, etc. Herein, we have developed a novel route to realize the rapid determination of concentration and configuration of primary amine-based chiral molecules. An aldehyde functionalized acid & base-sensitive fluorane dye (R-C) was used as the active agent to be reacted with the chiral molecules through an aldimine condensation reaction. After the mixing operation, concentration and configuration of the detected chiral molecule could be facilely read from the UV-vis absorption spectra and CD spectra, respectively.
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