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Rat shoulder contracture models: Techniques, evaluation, pathophysiology, and applications in developing treatment
Xiangnan Yuan1, Shengwen Feng1, Wanan Xiao2
1Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China.
Heliyon
|October 9, 2024
Summary
Rat shoulder contracture models are crucial for understanding disease and testing new therapies. This review details effective models and their role in developing treatments like relaxin-2 and platelet-rich plasma.
Area of Science:
- Orthopedics and Rehabilitation Science
- Animal Models in Biomedical Research
- Regenerative Medicine
Background:
- Shoulder contracture pathophysiology and treatment development rely on animal models.
- Rat models offer a valuable platform for studying shoulder contracture.
- Existing literature on rat shoulder contracture models requires comprehensive analysis.
Purpose of the Study:
- To review and analyze established rat models of shoulder contracture.
- To assess the pathological relevance of these models to human conditions.
- To explore the application of these models in developing novel treatment interventions.
Main Methods:
- Narrative review of existing literature on shoulder contracture models in rats.
- Evaluation of techniques for inducing shoulder contracture.
- Assessment of pathological findings and therapeutic outcomes in reviewed studies.
Main Results:
- Several rat shoulder contracture models (external/internal immobilization, intra-articular injection) show varying success.
- Pathological analyses confirm similarities between rat models and human shoulder contracture.
- Effective models have facilitated the development of treatments including relaxin-2, PRP, and others.
Conclusions:
- Rat shoulder contracture models are indispensable tools for etiological research.
- These models provide a foundation for investigating and developing new therapeutic strategies.
- Continued use of validated rat models will advance shoulder contracture treatment.
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