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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Rat shoulder contracture models: Techniques, evaluation, pathophysiology, and applications in developing treatment

Xiangnan Yuan1, Shengwen Feng1, Wanan Xiao2

  • 1Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China.

Heliyon
|October 9, 2024
PubMed
Summary

Rat shoulder contracture models are crucial for understanding disease and testing new therapies. This review details effective models and their role in developing treatments like relaxin-2 and platelet-rich plasma.

Keywords:
Animal modelsPathologyRatsShoulderShoulder contractureTreatment methods

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Area of Science:

  • Orthopedics and Rehabilitation Science
  • Animal Models in Biomedical Research
  • Regenerative Medicine

Background:

  • Shoulder contracture pathophysiology and treatment development rely on animal models.
  • Rat models offer a valuable platform for studying shoulder contracture.
  • Existing literature on rat shoulder contracture models requires comprehensive analysis.

Purpose of the Study:

  • To review and analyze established rat models of shoulder contracture.
  • To assess the pathological relevance of these models to human conditions.
  • To explore the application of these models in developing novel treatment interventions.

Main Methods:

  • Narrative review of existing literature on shoulder contracture models in rats.
  • Evaluation of techniques for inducing shoulder contracture.
  • Assessment of pathological findings and therapeutic outcomes in reviewed studies.

Main Results:

  • Several rat shoulder contracture models (external/internal immobilization, intra-articular injection) show varying success.
  • Pathological analyses confirm similarities between rat models and human shoulder contracture.
  • Effective models have facilitated the development of treatments including relaxin-2, PRP, and others.

Conclusions:

  • Rat shoulder contracture models are indispensable tools for etiological research.
  • These models provide a foundation for investigating and developing new therapeutic strategies.
  • Continued use of validated rat models will advance shoulder contracture treatment.