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The choroid plexus (ChP) plays a key role in central nervous system (CNS) diseases. Understanding ChP mechanisms offers new therapeutic targets for CNS conditions.

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Area of Science:

  • Neuroscience
  • Pathology
  • Immunology

Background:

  • The choroid plexus (ChP) is crucial for central nervous system (CNS) homeostasis.
  • Structural changes in the human ChP are observed in various diseases, but their physiological relevance is unclear.
  • The ChP's role in CNS pathology is increasingly recognized.

Purpose of the Study:

  • To review the roles of the ChP in CNS pathology.
  • To emphasize the ChP's involvement in disease mechanisms and therapeutic potential.
  • To highlight the ChP as a critical player in CNS homeostasis and pathology.

Main Methods:

  • Literature review synthesizing recent research on the ChP in CNS pathology.
  • Examination of primary ChP pathologies and their significance in neurologic disorders.
  • Analysis of the ChP's involvement in disease mechanisms, including stroke, hydrocephalus, infectious diseases, and neurodegeneration.

Main Results:

  • The ChP is implicated in various CNS diseases, acting as a disease driver, pathogen gateway, or neuroimmune orchestrator.
  • Structural changes in the ChP are associated with different pathologies.
  • The ChP's functions are vital for maintaining CNS homeostasis.

Conclusions:

  • The choroid plexus (ChP) is a critical player in CNS homeostasis and pathology.
  • Enhanced focus on ChP mechanisms can unlock new diagnostic and treatment strategies for CNS diseases.
  • The ChP holds significant promise as a therapeutic target for numerous CNS conditions.