New insights into the toxicity of lanthanides with functional genomics

As the use of lanthanides increases in many industries, concerns regarding their impact on human health rise. However, until recently, the toxicological profile of these elements had been incompletely characterized, with most studies relying on biodistribution assessments and lethal dose determinations in different animal models. In the last few years, the f-element field has started to pivot towards other examination types that identify cellular and molecular mechanisms of toxicity in a high-throughput manner. Under this new paradigm, functional genomics techniques, which rely on genetically modified cells or model organisms with missing genes or proteins, are becoming fundamental to gain novel insights into the genetic and proteomic bases of lanthanide toxicity, as well as to identify potential therapeutic targets to minimize the harmful effects of the metals. This review aims to provide an updated perspective on current efforts using functional genomics to characterize the toxicity and biological impact of lanthanides and improve their safety in different industrial applications.