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Updated: Jun 11, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

Comparative Toxicogenomics Database's 20th anniversary: update 2025.

Allan Peter Davis¹, Thomas C Wiegers¹, Daniela Sciaky¹

¹Department of Biological Sciences, 3510 Thomas Hall, 112 Derieux Place, North Carolina State University, Raleigh, NC 27695, USA.

Nucleic Acids Research

|October 10, 2024

Summary

This summary is machine-generated.

The Comparative Toxicogenomics Database (CTD) has grown significantly over 20 years, now linking over 94 million connections between environmental chemicals and human health. This update highlights new features and data content to aid environmental health research.

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Published on: June 17, 2015

Area of Science:

Environmental health
Toxicology
Bioinformatics

Background:

The Comparative Toxicogenomics Database (CTD) has provided literature-based toxicogenomic data for two decades.
CTD links chemicals to genes, proteins, phenotypes, diseases, and exposures, supporting environmental health research.
The database has experienced substantial growth in data content and features.

Purpose of the Study:

To commemorate CTD's 20th anniversary by reflecting on its growth.
To provide an overview of CTD's expanded data content and new functionalities.
To highlight improvements in curation, tools, and infrastructure.

Main Methods:

Literature-based curation of toxicogenomic information.
Integration of controlled vocabularies for linking lab and exposure data.
Enhancements to curation workflows, including natural language processing and new tools.
Upgrades to software and infrastructure for improved functionality.

Main Results:

CTD now contains over 94 million toxicogenomic connections.
New features include an exposure curation tool, improved CTD Tetramers, and Pathway View.
Enhanced curation and infrastructure support analysis across the environmental health continuum.

Conclusions:

CTD has evolved from a prototype to a premier knowledgebase for environmental health discovery.
The database facilitates hypothesis generation for scientists studying chemical impacts on human health.
Continued development enhances CTD's utility for understanding the molecular to population-level effects of environmental exposures.