Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Conduction System of the Heart

Conduction System of the Heart

Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mavacamten and left ventricular dysfunction in hypertrophic cardiomyopathy with left bundle branch block.

Progress in cardiovascular diseases·2026

Same author

Long-term performance of conduction system pacing in patients with congenital heart disease.

Heart rhythm·2026

Same author

Rationale and Design of the PREDICT-CCM Study: Predictive Value of Dobutamine Stress Echocardiography for Clinical Response to Cardiac Contractility Modulation Therapy in a Multicenter Italian Cohort.

Journal of clinical medicine·2026

Same author

Mechanical resynchronization in left bundle branch block achieved by conduction system pacing: A strain-based analysis.

Heart rhythm·2026

Same author

Can we rely on remote electrogram analysis to monitor long-term conduction system capture in left bundle branch area pacing?

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026

Same author

Interatrial Conduction Pacing: All Roads May Lead to Rome, But Which One Should We Take?

JACC. Case reports·2026

Same journal

Prevalence and Discrimination of On-going Fibrillation in Isolated Pulmonary Vein in Non-paroxysmal AF Ablation.

Arrhythmia & electrophysiology review·2026

Same journal

Who Benefits Most? Patient Selection for Atrial Fibrillation Catheter Ablation in Heart Failure.

Arrhythmia & electrophysiology review·2026

Same journal

Idiopathic Ventricular Arrhythmias: Map Meticulously, Ablate Sparingly.

Arrhythmia & electrophysiology review·2026

Same journal

T Wave Oversensing in Left Bundle Branch Optimised CRT.

Arrhythmia & electrophysiology review·2026

Same journal

Radiofrequency Catheter Ablation for Arrhythmia-induced Cardiomyopathy in Infants: A Case Series and Literature Review.

Arrhythmia & electrophysiology review·2026

Same journal

Device-detected Atrial Fibrillation: How Much is Too Much?

Arrhythmia & electrophysiology review·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 11, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Stylet-driven Leads or Lumenless Leads for Conduction System Pacing.

Óscar Cano^1,2, Jan De Pooter³, Francesco Zanon⁴

¹Unidad de Arritmias, Hospital Universitario y Politécnico La Fe Valencia, Spain.

Arrhythmia & Electrophysiology Review

|October 10, 2024

Summary

This summary is machine-generated.

New stylet-driven leads for conduction system pacing show comparable performance to older lumenless leads. The choice between lead types depends on the implanter

Keywords:

Conduction system pacing His bundle pacing left bundle branch area pacing lumenless lead stylet-driven lead

More Related Videos

Translational Rabbit Model of Chronic Cardiac Pacing

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Related Experiment Videos

Last Updated: Jun 11, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Translational Rabbit Model of Chronic Cardiac Pacing

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Area of Science:

Cardiovascular Medicine
Electrophysiology
Medical Device Technology

Background:

Conduction system pacing is evolving with the introduction of stylet-driven leads.
Previous experience primarily utilized lumenless leads, presenting distinct design and implantation characteristics.
Significant differences in design and structure necessitate unique implantation techniques and learning curves for each lead type.

Purpose of the Study:

To compare the clinical outcomes and performance of stylet-driven leads versus lumenless leads in conduction system pacing.
To evaluate if specific clinical scenarios favor one lead type over the other.

Main Methods:

Review of existing literature and clinical data comparing stylet-driven and lumenless leads.
Analysis of design characteristics, implantation techniques, and reported performance metrics.
Assessment of available data on direct clinical outcome comparisons.

Main Results:

Lead performance between stylet-driven and lumenless leads appears comparable.
Data directly comparing clinical outcomes between the two lead types are limited.
No specific clinical scenarios currently favor one lead type over the other.

Conclusions:

Both stylet-driven and lumenless leads demonstrate comparable lead performance in conduction system pacing.
The selection between stylet-driven and lumenless leads should be based on the individual implanter's experience due to differing techniques and learning curves.
Further research is needed to directly compare clinical outcomes and identify potential differentiating factors.