A comprehensive review of transduction methods of lectin-based biosensors in biomedical applications

Biosensors have emerged as a pivotal technology in the biomedical field, significantly enhancing the rapidity and precision of biomolecule detection. These advancements are instrumental in refining diagnostic processes, optimizing treatments, and monitoring diseases more effectively. Central to the development of highly sensitive, selective, and stable biosensors are the bioreceptor and transducer components. This review paper discusses the use of lectin as a bioreceptor and explores the prevalent transducer methods employed in lectin-based biosensors, with a particular emphasis on their applications in biomedical research. The paper meticulously examines various transducers, with a spotlight on electrochemical and optical transduction methods, drawing from a wealth of previous studies to offer a comprehensive perspective on the application of these sensors in critical biomedical areas. These areas include early diagnosis, therapeutic interventions, and continuous health monitoring. Moreover, the review addresses the challenges of implementing lectin-based biosensors, such as specificity and stability issues. It also explores future possibilities, examining potential trends to overcome these challenges. In summary, this comprehensive analysis aspires to equip researchers with profound insights into the transformative potential of lectin-based biosensors, underscoring their significant role in the evolution of biomedical research and the broader healthcare landscape.