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Updated: Jun 11, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Aliphatic Nitrile Template Enabled meta-C-H Olefination of Indene Enoate Esters under Microwave Accelerating
Kurella Mounika1, Gedu Satyanarayana1
1Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana 502284, India.
Abstract:
Site-selective activation of a particular remote C-H bond in molecules with multiple C-H bonds remains challenging in organic synthesis. In addition, evolving such transformations via the utilization of unconventional techniques is highly desirable. We demonstrated hitherto unexplored double bond geometry-guided and end-on nitrile-template-assisted meta-C-H functionalization of indene enoate esters under microwave-accelerated conditions. Significantly, the strategy exhibited broad compatibility concerning the substrates and olefin coupling partners. Remarkably, drug diversification has also been showcased.
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