Related Experiment Video

Updated: Jun 10, 2025

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
06:15

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

12.8K

Relationships Among Stress, Diabetes Distress, and Biomarkers in Children with Type 1 Diabetes Mellitus from Diverse

Sara L Davis, Sarah S Jaser, Nataliya Ivankova

    Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners
    |October 10, 2024
    PubMed

    Insights

    Perceived stress significantly impacts glycemic control in children with type 1 diabetes. Interventions should address stress to improve health outcomes, particularly in underrepresented populations.

    Area of Science:

    • Pediatric Endocrinology
    • Diabetes Research
    • Psychoneuroimmunology

    Background:

    • Type 1 diabetes (T1DM) management in children requires understanding factors affecting glycemic control.
    • Glycemic levels can be influenced by psychosocial and physiological stressors.
    • Disparities in T1DM outcomes exist among different racial groups.

    Purpose of the Study:

    • To investigate factors negatively impacting glycemic levels in Black and White children (8-12 years) with T1DM.
    • To examine the relationship between perceived stress, diabetes distress, and glycemic control.
    • To explore the potential mediating roles of cortisol and inflammatory biomarkers.

    Main Methods:

    • Quantitative, cross-sectional study involving 34 children with T1DM and their parents.
    • Measurements included perceived stress, diabetes distress, salivary cortisol, inflammatory biomarkers (IL-8), and hemoglobin A1c (HbA1c).
    • Data collected via self-report surveys and biological samples (blood, saliva).

    Main Results:

    • Most children did not meet American Diabetes Association (ADA) HbA1c recommendations.
    • Black children exhibited higher HbA1c levels compared to White children.
    • Significant medium-to-large effect sizes were observed between perceived stress and HbA1c.
    • Cortisol and IL-8 may mediate the stress-HbA1c relationship.

    Conclusions:

    • Elevated glycemic levels in children with T1DM are influenced by perceived stress.
    • Psychosocial factors and biomarkers like cortisol and IL-8 play a role in T1DM glycemic control.
    • Tailored interventions are needed for low-income and underrepresented populations to improve T1DM outcomes.
    Abstract

    Keywords:
    biomarkersglycemic controlstressunderrepresented populations

    More Related Videos

    Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting11:31

    Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

    Published on: November 30, 2015

    16.0K
    A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

    A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

    Published on: July 5, 2022

    2.7K

    Related Concept Videos

    Psychoneuroimmunology: Diabetes and Cancer01:19

    Psychoneuroimmunology: Diabetes and Cancer

    Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
    24
    Diabetes Mellitus: Overview and Type I Subtype01:22

    Diabetes Mellitus: Overview and Type I Subtype

    Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
    Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
    2.5K
    Pathophysiology of Diabetes01:20

    Pathophysiology of Diabetes

    Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
    Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
    881
    Diabetes: Symptoms, Diagnosis, and Complications01:15

    Diabetes: Symptoms, Diagnosis, and Complications

    For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
    512
    Diabetes Mellitus: Type 2 and Gestational01:22

    Diabetes Mellitus: Type 2 and Gestational

    Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
    2.2K
    Introduction to Stress and Lifestyle01:27

    Introduction to Stress and Lifestyle

    Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
    86