Related Experiment Video
Updated: May 3, 2026
Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction
Published on: April 1, 2019
Revisiting Unaddressed Safety Concerns Regarding Intense Pulsed Light Treatment: Past and Present Perspectives
Mao-Ying Lin1, Tak-Wah Wong2,3, Chrang-Shi Lin4,5
1Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, Fujian, China.
Intense pulsed light (IPL) treatments can cause skin damage, including cellular senescence and photoaging, due to harmful biomarkers. Proper protocols and candidate selection are crucial for safe IPL therapy.
Area of Science:
- Dermatology
- Photobiology
- Aesthetics
Background:
- Intense pulsed light (IPL) utilizes visible to near-infrared light spectrum.
- IPL has been a staple in aesthetic treatments for three decades.
- Undesirable skin biomarkers post-IPL irradiation require further elucidation.
Purpose of the Study:
- To review evolving concepts of IPL.
- To explore potentially neglected harmful effects of IPL.
Main Methods:
- Literature review of existing studies on IPL.
- Analysis of biomarkers associated with IPL treatment.
Main Results:
- IPL irradiation increased oxidative stress and specific biomarkers (p53, p16, PCNA, IL-6, CRP, cleaved caspase 3).
- Albumin levels decreased post-IPL treatment.
- Visible and infrared light exhibit both detrimental and beneficial effects on skin.
Conclusions:
- Improper IPL may induce cellular senescence, photoaging, photocarcinogenesis, thermal aging, and inflammaging.
- Further research is needed to validate biomarker significance.
- Optimized protocols, parameter selection, and candidate screening are essential for safe IPL therapy.
More Related Videos
11:04An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
03:47Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
Published on: September 27, 2024
