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Updated: Jun 10, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
The hidden costs of aneuploidy: New insights from yeast
Yuerong Wang1, Xian Fu2, Yue Shen2
1College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; BGI Research, Changzhou 213299, China; BGI Research, Shenzhen 518083, China; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen 518083, China.
Abstract:
The molecular mechanisms underlying the paradoxical effects1 of aneuploidy are still not completely understood. In this issue, Rojas et al.2 systematically analyzed the associated costs of aneuploidy and the molecular drivers involved, which revealed that aneuploidy stress is primarily driven by the cumulative effects of genes per chromosome. Notably, gene length was predicted as the most significant indicator of aneuploidy toxicity by machine learning.
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