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Related Experiment Video

Updated: Jun 10, 2025

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

Postamputation Pain Management.

Merideth Byl¹, Jennifer Tram¹, Brandon Kalasho¹

¹Department of Physical Medicine & Rehabilitation, Greater Los Angeles Veteran Affairs HealthCare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA; Division of PM&R, Department of Medicine, 200 UCLA Medical Plaza, Suite 420, Los Angeles, CA 90095, USA.

Physical Medicine and Rehabilitation Clinics of North America

|October 10, 2024

Summary

Postamputation pain, including residual and phantom limb pain, is complex to treat. A multimodal approach combining medications, therapy, and support is recommended for effective management.

Keywords:

Perioperative pain Phantom limb pain Postamputation pain Rehabilitation Residual limb pain

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Last Updated: Jun 10, 2025

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

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Published on: March 8, 2024

Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model

Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model

Published on: September 20, 2021

Area of Science:

Pain Management
Neurology
Rehabilitation Medicine

Background:

Postamputation pain is a prevalent and difficult condition.
It encompasses residual limb pain (at or near the amputation site) and phantom limb pain (distal to the amputation site).
Causes include poor wound healing, prosthetic issues, neuropathic pain, and supraspinal reorganization.

Purpose of the Study:

To review the nature and treatment of postamputation pain.
To highlight the importance of a comprehensive management strategy.

Main Methods:

Literature review of postamputation pain conditions.
Synthesis of current treatment modalities.

Main Results:

Residual limb pain can stem from local factors or neuropathic origins.
Phantom limb pain is often linked to central nervous system changes.
Effective management requires a combination of therapies.

Conclusions:

Postamputation pain necessitates a multimodal and multidisciplinary treatment approach.
Pharmacologic agents, rehabilitation, psychosocial support, and integrative therapies are key components.
Refractory cases may benefit from surgical interventions like neuromodulation.