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Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
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Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
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PHACE syndrome: A review.

Louisa Keith1

  • 1Department of Neurology, Dell Medical School, The University of Texas at Austin, 1601 Trinity St., Bldg. B, Stop Z0700, Austin, TX 78712, United States.

Seminars in Pediatric Neurology
|October 10, 2024
PubMed
Summary

PHACE syndrome is a rare neurocutaneous disorder affecting brain, arteries, and heart. Early recognition and management are crucial for pediatric neurologists to address potential neurological complications like stroke.

Keywords:
ArteriopathyCerebrovascular anomalyHemangiomaMultiple congenital anomaliesNeurocutaneous syndromePediatric stroke

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Area of Science:

  • Neurology
  • Pediatrics
  • Genetics

Background:

  • PHACE syndrome is a complex neurocutaneous disorder.
  • It involves posterior fossa brain abnormalities, facial infantile hemangioma, arterial, cardiac, and eye anomalies.
  • Extracutaneous arterial abnormalities are common and pose significant risks.

Purpose of the Study:

  • To review the clinical features, diagnosis, epidemiology, and management of PHACE syndrome.
  • To emphasize neurological sequelae relevant to pediatric neurologists.
  • To increase awareness of this disorder among healthcare professionals.

Main Methods:

  • Literature review of PHACE syndrome.
  • Synthesis of clinical data and management strategies.
  • Focus on neurological and vascular manifestations.

Main Results:

  • PHACE syndrome presents with diverse abnormalities, notably infantile hemangiomas and vascular defects.
  • Cerebral arteriopathy can lead to progressive neurological issues, including stroke.
  • Associated cardiac and eye anomalies require multidisciplinary care.

Conclusions:

  • Pediatric neurologists must be familiar with PHACE syndrome.
  • Early diagnosis and management are vital to mitigate severe neurological outcomes.
  • A comprehensive approach is necessary for optimal patient care.