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Updated: Jun 10, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Advancements in Biologic Therapies for Eosinophilic Gastrointestinal Diseases: A Comprehensive Review
Racha Abi Melhem1, Yasmin Hassoun2
1Department of Internal Medicine, Staten Island University Hospital, 300 Constitution Avenue, Apartment 109, Bayonne, NJ 07002, USA.
Abstract:
Eosinophilic gastrointestinal diseases (EGIDs) encompass a group of disorders characterized by an abnormal accumulation of eosinophils in various parts of the gastrointestinal tract. EGIDs present with a wide range of symptoms such as abdominal pain, vomiting, diarrhea, difficulty swallowing, and food impaction. Monoclonal antibodies, targeting inflammatory cytokines or eosinophils, are the next emerging therapy for EGIDs. The only Food and Drug Administration-approved monoclonal antibody is dupilumab, and it has been approved for the treatment of eosinophilic esophagitis (EoE). In this article, the authors will discuss biologics that have been used in the treatment of eosinophilic gastrointestinal diseases.
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