Related Experiment Video
Updated: Jun 10, 2025
09:36
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
2.7K
Premedication for less invasive surfactant administration: a narrative review
Claire A Murphy1, Kevin Cw Goss2, Rebeccah Slater3
1Neonatal Medicine, Chelsea and Westminster Healthcare NHS Trust, London, UK drclaireamurphy@gmail.com.
Archives of Disease in Childhood. Fetal and Neonatal Edition
|October 10, 2024
Summary
Less invasive surfactant administration (LISA) for preterm infants requires effective pain management. This review examines current knowledge and evidence gaps on premedication strategies to optimize comfort during LISA procedures.
Area of Science:
- Neonatal medicine
- Pediatric respiratory care
Background:
- Less invasive surfactant administration (LISA) is a common method for treating respiratory distress syndrome in preterm infants.
- Optimal pain and discomfort management during LISA, while preserving spontaneous breathing, is not well-defined.
- Clinical practice varies widely due to limited evidence guiding premedication choices.
Purpose of the Study:
- To review current knowledge on premedication for LISA.
- To identify evidence gaps concerning pain management during LISA procedures.
- To provide guidance for clinicians on optimizing patient comfort during LISA.
Main Methods:
- Literature search for studies on premedication prior to LISA.
- Synthesis of existing evidence on pharmacological and non-pharmacological interventions.
- Analysis of current clinical practices and variations.
Main Results:
- Limited evidence exists on the efficacy and safety of various premedication options for LISA.
- Specific data on maintaining spontaneous respiration during premedication is scarce.
- Significant variability in current clinical approaches to LISA premedication was observed.
Conclusions:
- Further research is needed to establish optimal premedication protocols for LISA.
- Evidence-based guidelines are required to standardize pain management during LISA.
- Addressing knowledge gaps will improve preterm infant care during surfactant administration.
Related Concept Videos
01:05Breathing
58.7K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
58.7K
01:20Inhalational Anesthetics: Overview
218
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
218
01:17Drugs Used in Lower Respiratory Disorders: Overview
356
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
356
01:23Inhaled Medications
237
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
237
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
235
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
235
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K