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Updated: Jun 10, 2025

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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Premedication for less invasive surfactant administration: a narrative review

Claire A Murphy1, Kevin Cw Goss2, Rebeccah Slater3

  • 1Neonatal Medicine, Chelsea and Westminster Healthcare NHS Trust, London, UK drclaireamurphy@gmail.com.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|October 10, 2024
PubMed

Less invasive surfactant administration (LISA) is an increasingly popular technique to deliver surfactant to spontaneously breathing preterm infants with respiratory distress syndrome. The optimal method of alleviating the pain and discomfort associated with LISA, either pharmacological or non-pharmacological, while maintaining spontaneous respiration remains unclear. There is limited evidence to guide clinicians, resulting in wide variations in practice. The aim of this article is to summarise the current knowledge and evidence gaps regarding the use of premedication prior to LISA.

Keywords:
AnalgesiaIntensive Care Units, NeonatalNeonatologyPainPharmacology

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