Inhibition of nucleoside diphosphate reductase by hydroxybenzohydroxamic acid derivatives

Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells.

British journal of haematology·2006

Short-term treatment with novel ribonucleotide reductase inhibitors Trimidox and Didox reverses late-stage murine retrovirus-induced lymphoproliferative disease with less bone marrow toxicity than hydroxyurea.

Antiviral chemistry & chemotherapy·2003

Activation of caspases and induction of apoptosis by novel ribonucleotide reductase inhibitors amidox and didox.

Experimental hematology·2001

The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells.

Life sciences·2001

Trimidox, an inhibitor of ribonucleotide reductase, induces apoptosis and activates caspases in HL-60 promyelocytic leukemia cells.

Experimental hematology·2000

Enhancement of hemoglobin and F-cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with streptozotocin.

American journal of hematology·2000

Antimicrobial photodynamic therapy across ESKAPE pathogens: Efficacy, limitations, and a pathogen-adapted framework toward clinical translation.

Pharmacology & therapeutics·2026

Prospects for treatment of cerebral ischemic stroke with Hydroxysafflower Yellow A.

Pharmacology & therapeutics·2026

Targeting metabolic reprogramming in cancer: Past, present, and future.

Pharmacology & therapeutics·2026

Targeting glycine transporter type 1 (GlyT1) in epilepsy: Pathophysiological rationale and therapeutic perspectives.

Pharmacology & therapeutics·2026

The brain angiotensin converting enzyme 2 and angiotensin-(1-7) as potential therapeutic targets for the central nervous system diseases.

Pharmacology & therapeutics·2026

Mechanisms of 'metabolizeaccretion' and therapeutic targets in influenza infection.

Pharmacology & therapeutics·2026

Almost 200 years of anthocyanin research: What we know, what we assume and what remains unknown.

Plant biology (Stuttgart, Germany)·2026

Intramolecular TDDA Approach to the Dihydrobenzopentalene Skeleton of Aromatized Nine-Membered Enediyne Antibiotics.

The Journal of organic chemistry·2026

Synthesis, Structure, and Antileishmanial Activity of Novel 1,2,4-Trioxolanes, 1,2,4,5-Tetraoxanes and Their Respective Deoxygenated Controls.

ChemMedChem·2026

Phenolic compounds from Coreopsis tinctoria Nutt. and their anti-inflammatory activity.

Phytochemistry·2026

Related Experiment Videos

Inhibition of nucleoside diphosphate reductase by hydroxybenzohydroxamic acid derivatives

Related Concept Videos

Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells.

Short-term treatment with novel ribonucleotide reductase inhibitors Trimidox and Didox reverses late-stage murine retrovirus-induced lymphoproliferative disease with less bone marrow toxicity than hydroxyurea.

Activation of caspases and induction of apoptosis by novel ribonucleotide reductase inhibitors amidox and didox.

The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells.

Trimidox, an inhibitor of ribonucleotide reductase, induces apoptosis and activates caspases in HL-60 promyelocytic leukemia cells.

Enhancement of hemoglobin and F-cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with streptozotocin.

Antimicrobial photodynamic therapy across ESKAPE pathogens: Efficacy, limitations, and a pathogen-adapted framework toward clinical translation.

Prospects for treatment of cerebral ischemic stroke with Hydroxysafflower Yellow A.

Targeting metabolic reprogramming in cancer: Past, present, and future.

Targeting glycine transporter type 1 (GlyT1) in epilepsy: Pathophysiological rationale and therapeutic perspectives.

The brain angiotensin converting enzyme 2 and angiotensin-(1-7) as potential therapeutic targets for the central nervous system diseases.

Mechanisms of 'metabolizeaccretion' and therapeutic targets in influenza infection.

Almost 200 years of anthocyanin research: What we know, what we assume and what remains unknown.

Intramolecular TDDA Approach to the Dihydrobenzopentalene Skeleton of Aromatized Nine-Membered Enediyne Antibiotics.

Synthesis, Structure, and Antileishmanial Activity of Novel 1,2,4-Trioxolanes, 1,2,4,5-Tetraoxanes and Their Respective Deoxygenated Controls.

Phenolic compounds from Coreopsis tinctoria Nutt. and their anti-inflammatory activity.

Related Experiment Videos

Inhibition of nucleoside diphosphate reductase by hydroxybenzohydroxamic acid derivatives

Related Concept Videos

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