[Antidepressive prevention with lithium salts: possible interaction with occupational exposure to nephrotoxic...

Forty-four patients suffering from depressive disorders treated with lithium have been subdivide in two groups. One of groups included subjects with previous working anamnesis of exposure to renal toxic agents. The differences of renal function between the two groups have been considered. Significant differences of glomerular and tubular function have been found. These findings permit to hypothesize a synergism between lithium and nephrotoxic agents.