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Updated: Jun 10, 2025

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

Innervation in corneal bioengineering.

Clare Maher¹, Zhi Chen², Ying Zhou²

¹Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Fairy Meadow, New South Wales, Australia; School of Medicine, University of Notre Dame, Sydney, NSW, Australia.

Acta Biomaterialia

|October 11, 2024

Summary

This summary is machine-generated.

Functional nerve regeneration is key for bioengineered corneas. This review explores materials, techniques, and challenges for achieving successful corneal innervation, aiming to improve their stability and longevity.

Keywords:

Bioengineering Biomaterials Cornea Innervation

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Area of Science:

Biomaterials Science
Ophthalmology
Tissue Engineering

Background:

Corneal nerves are vital for function and integrity.
Current bioengineered corneas lack complete functional innervation.
Successful nerve regeneration is crucial for engineered cornea longevity.

Purpose of the Study:

To review materials and fabrication techniques for enhancing innervation in bioengineered corneas.
To discuss approaches and assessment methods for corneal nerve regeneration.
To identify challenges and future directions in innervated bioengineered cornea research.

Main Methods:

Comprehensive literature review of materials and fabrication techniques.
Analysis of approaches to facilitate and assess corneal innervation.
Evaluation of in vitro and in vivo studies on bioengineered corneas.

Main Results:

No current bioengineered cornea fully replicates native corneal complexity and innervation.
Various materials and fabrication methods show promise for enhancing nerve regeneration.
Standardized methods for assessing innervation are needed.

Conclusions:

Achieving functional nerve regeneration is critical for viable bioengineered corneas.
Further research is needed to overcome challenges in replicating corneal innervation.
This review provides guidance for future development of innervated bioengineered corneas.