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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Updated: Jun 10, 2025

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
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From Fetus to Eight: the CHILD Cohort Study.

Kozeta Miliku1,2, Myrtha E Reyna3,4, Maria Medeleanu3,5

  • 1Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

American Journal of Epidemiology
|October 11, 2024
PubMed
Summary

The CHILD Cohort Study tracks Canadian infants to understand how early environments and biology impact chronic diseases like asthma and neurodevelopmental disorders. High retention rates ensure robust data for lifelong health insights.

Keywords:
CHILD cohort studyallergiesasthmacardiovascular healthdata science platformenvironmentgenesgrowth trajectorieslongitudinal prospective population-based studymental healthmicrobiomenormative cohortobesitypediatrics

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Area of Science:

  • Pediatric Epidemiology
  • Life-Course Health Research
  • Environmental Health

Background:

  • The Canadian CHILD Cohort Study is a prospective, multi-center pregnancy cohort.
  • It follows Canadian infants from fetal life to adulthood.
  • Focuses on non-communicable diseases (NCDs) and multimorbidity.

Purpose of the Study:

  • To investigate interactions between early life environments (physical, psychosocial) and biological factors.
  • To understand influences on NCD outcomes such as asthma, allergic disorders, growth, cardio-metabolic, and neurodevelopmental health.
  • To establish a data science platform for NCD research.

Main Methods:

  • Longitudinal data collection with detailed clinical and physiological phenotyping.
  • Environmental, biological (microbiome, genetics, epigenetics), nutritional, and actigraphy/GPS sampling.
  • High participant retention (90.7% at 8 years) and a COVID-19 sub-cohort.

Main Results:

  • High retention rates demonstrate cohort's long-term viability.
  • Successful adaptation to pandemic conditions via virtual visits.
  • Ongoing data collection for 13-year assessments.

Conclusions:

  • The CHILD Cohort Study provides a rich dataset for understanding chronic disease development.
  • Highlights the critical role of early life exposures and biological factors.
  • Aims to inform public health strategies for preventing NCDs and multimorbidity.