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Micropapillary pattern in colorectal cancer: an Australian multicentre experience
Supun Madushani Bakmiwewa1,2, Jason Diab1,2,3, Dinuke De Silva4
1Department of Colorectal Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia.
ANZ Journal of Surgery
|October 12, 2024
Summary
Micropapillary carcinoma (MPC) is an under-recognized colorectal cancer subtype. This Australian study found MPC linked to aggressive features and poorer survival, highlighting its importance for prognostication and treatment.
Area of Science:
- Oncology
- Pathology
- Cancer Research
Background:
- Colorectal cancer is a leading global malignancy.
- Micropapillary carcinoma (MPC) is a recognized poor prognostic marker in other cancers.
- MPC is an under-recognized subtype in colorectal cancer.
Purpose of the Study:
- To evaluate the prevalence of MPC in colorectal cancer.
- To assess the implications and survival impact of MPC in an Australian cohort.
Main Methods:
- Retrospective review of colorectal cancer resections (2019-2024) from two Australian tertiary centers.
- Histopathological identification of MPC.
- Collection of clinicopathological variables including TNM staging, lymphovascular invasion (LVI), and lymph node involvement.
Main Results:
- MPC identified in 3.5% (21/597) of cases.
- MPC cases predominantly featured advanced T-stage (95% T3-T4), lymph node involvement (90%), and LVI (86%).
- Overall 3-year survival for MPC patients was 76%.
Conclusions:
- MPC in colorectal cancer is associated with high-risk pathological features.
- Accurate histopathological diagnosis of MPC is crucial for prognostication.
- Identifying MPC can guide individualized adjuvant therapy and surveillance strategies.
