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Related Experiment Videos

Cancer risks posed by aflatoxin M1.

D P Hsieh, J M Cullen, L S Hsieh

    Princess Takamatsu Symposia
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Aflatoxin M1 (AFM) in milk showed carcinogenicity at 50 ppb in rats, but posed a very low cancer risk to adults. Further infant studies are needed due to milk

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    Area of Science:

    • Toxicology
    • Food Safety
    • Carcinogenesis

    Background:

    • Aflatoxin M1 (AFM) is a suspect milk-borne carcinogen.
    • Aspergillus flavus fungus produces AFM.

    Purpose of the Study:

    • To determine the carcinogenicity and potency of AFM.
    • To assess cancer risk from AFM in milk.

    Main Methods:

    • Rats were fed diets with AFM at 0, 0.5, 5, and 50 ppb for 19-21 months.
    • Aflatoxin B1 (AFB) served as a positive control.
    • Hepatocarcinogenicity and intestinal tumors were evaluated.

    Main Results:

    • AFM at 50 ppb caused hepatocarcinogenicity and intestinal tumors.
    • AFM potency was 2-10% of AFB.
  • AFM at 0.5 ppb stimulated rat growth without liver lesions.

    • Conclusions:

    • AFM poses a very low cancer risk to human adults.
    • Infant exposure to AFM warrants further investigation.
    • AFM at 0.5 ppb, the FDA action level, did not induce liver lesions.