Synthesis of a Bioactive Nitric Oxide-Releasing Polymer from S-Nitrosated Starch

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Medical Devices

Background:

• Nitric oxide (NO) incorporation into polymers enhances stability and enables controlled release.
• Applications of NO-releasing polymers span medical dressings, food packaging, and implantable devices.

Purpose of the Study:

• To develop an economical and straightforward method for manufacturing bioactive nitric oxide-releasing polymer (BioNOR-P).
• To evaluate the bactericidal, antioxidant, mechanical, cytotoxic, and genotoxic properties of the developed BioNOR-P.

Main Methods:

• BioNOR-P films were fabricated using a casting method.
• Nitric oxide release kinetics were measured in an aqueous medium.
• Antioxidant activity, mechanical properties, cytotoxicity, and genotoxicity were assessed.

Main Results:

• The casting method yielded a homogeneous, transparent BioNOR-P film with favorable mechanical characteristics.
• The film exhibited a sustained nitric oxide release rate of 0.58 nmol/g⁻¹ min⁻¹.
• The material demonstrated non-cytotoxicity, significant antioxidant activity, and effective bacterial growth inhibition.

Conclusions:

• The developed BioNOR-P offers a promising platform for nitric oxide delivery with potential in diverse applications.
• The material's properties support its future use in areas requiring antimicrobial and antioxidant functionalities.