Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Introduction to Stress and Lifestyle

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

Psychological Responses to Stress

Psychological Responses to Stress

Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...

Types of Stressors

Types of Stressors

A stressor is any event, condition, or stimulus that triggers stress and causes a physical or psychological response in the body. Stressors can be categorized into three main types: catastrophes; significant life changes; and daily hassles, including social stress. Each can be detrimental to physical and mental well-being.
Catastrophes
Catastrophes refer to large-scale, unpredictable events that create overwhelming stress and a sense of threat. Examples include natural disasters like...

Physiological Foundation of Stress

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The 2025-2030 Dietary Guidelines for Americans are associated with higher land, water and nitrogen use, and greenhouse gas emissions.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Modeling the impact of venous collapsibility on retinal oxygenation.

Journal of theoretical biology·2026

Same author

Modeling Pressure-Dependent Wave and Vessel Compliance in the Brain Following Middle Cerebral Artery Occlusion.

Microcirculation (New York, N.Y. : 1994)·2026

Same author

Dietary assessment at the confluence of public and planetary health: introduction of the DIEM (Dietary Impacts on Environmental Measures) scoring system.

Frontiers in nutrition·2025

Same author

Perspective: Nutrition Research & Programming in Multicultural Populations: The Fixed-Quality Variable-Type (FQVT) Dietary Intervention.

Advances in nutrition (Bethesda, Md.)·2025

Same author

Impact of Vascular Network Structure Heterogeneity on Retinal Tissue Oxygenation.

La matematica·2025

Same journal

The Earth BioGenome Project Phase II: illuminating the eukaryotic tree of life.

Frontiers in science·2026

Same journal

Precision cardiovascular medicine: shifting the innovation paradigm.

Frontiers in science·2025

Same journal

The future of evolutionary medicine: sparking innovation in biomedicine and public health.

Frontiers in science·2023

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 10, 2025

Author Spotlight: Unveiling Mechanisms of Stress Resilience - Significant Findings, Advancements, and Future Research

Author Spotlight: Unveiling Mechanisms of Stress Resilience - Significant Findings, Advancements, and Future Research

Published on: December 15, 2023

A multiscale inflammatory map: linking individual stress to societal dysfunction.

Yoram Vodovotz^1,2, Julia Arciero³, Paul Fmj Verschure⁴

¹Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.

Frontiers in Science

|October 14, 2024

Summary

This summary is machine-generated.

Inflammation drives stress, impacting individual cognition and societal dysfunction. A new model explores how this biological process links personal stress to global challenges, necessitating multiscale interventions for resilience.

Keywords:

climate change inflammation mathematical model social media society stress

More Related Videos

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test

The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test

Published on: November 19, 2015

Related Experiment Videos

Last Updated: Jun 10, 2025

Author Spotlight: Unveiling Mechanisms of Stress Resilience - Significant Findings, Advancements, and Future Research

Author Spotlight: Unveiling Mechanisms of Stress Resilience - Significant Findings, Advancements, and Future Research

Published on: December 15, 2023

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test

The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test

Published on: November 19, 2015

Area of Science:

Neuroscience
Immunology
Ecology

Background:

Global stress levels are rising, impacting human and planetary health.
Understanding the links between stress, inflammation, cognition, and behavior is crucial.

Purpose of the Study:

To propose a 'central inflammation map' hypothesis linking individual stress to societal and environmental impacts.
To present a mathematical model for analyzing stress, inflammation, and resilience at individual and societal levels.

Main Methods:

Hypothesized a multiscale role for inflammation as a driver of stress responses.
Developed a mathematical model to test links between stress, inflammation, control, and healing.
Considered implications of stressor transmission and intervention strategies.

Main Results:

Inflammation may act as a multiscale connector between individual stressors and large-scale dysfunction.
Interdependent neural and inflammatory processes can amplify stressors via digital communication.
The model illustrates potential detrimental effects on decision-making and problem-solving at scale.

Conclusions:

A coordinated, interdisciplinary research effort is needed to understand the multiscale nature of stress.
Multilayered interventions, including lifestyle changes and precision therapeutics, are essential for stress mitigation.
Addressing stress requires improving individual and community resilience to mitigate adverse global effects.