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CT-Based Adaptive Short Course Radiotherapy for Rectal Cancer: A Case Report
Jonathan Henning1, Sylvia Choo1, Pranit Singh1
1Radiation Oncology, University of South Florida Morsani College of Medicine, Tampa, USA.
Cureus
|October 14, 2024
Summary
Short-course radiotherapy (SCRT) with adaptive planning is a feasible rectal cancer treatment. This approach effectively delivered radiation doses in a metastatic case, offering potential for dose escalation.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Imaging
Background:
- Rectal cancer is a prevalent malignancy with evolving treatment strategies.
- Short-course radiotherapy (SCRT) combined with chemotherapy is a viable option within total neoadjuvant therapy for non-metastatic disease.
- SCRT offers logistical advantages and less disruption to systemic therapy compared to conventional chemoradiation, especially for metastatic cases.
Observation:
- A case report details a 42-year-old male with metastatic rectal cancer.
- The patient received CT-based adaptive SCRT, delivering 25 Gy to the pelvis and a 30 Gy simultaneous integrated boost to the rectal tumor over five fractions.
- The adaptive SCRT was observed to be effective and well-tolerated.
Findings:
- CT-based adaptive radiation demonstrated efficacy and good tolerability in this metastatic rectal cancer case.
- The treatment facilitated a pathway for isotoxic radiotherapy dose escalation in patients deemed inoperable.
Implications:
- Adaptive SCRT represents a promising strategy for managing rectal cancer, particularly in metastatic settings.
- This approach may enhance treatment outcomes by enabling dose escalation.
- The integration of adaptive techniques in SCRT warrants further investigation for broader clinical application.
