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Related Experiment Video

Updated: Jun 10, 2025

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Methamphetamine abuse impairs sequential working memory.

Wang Yao¹, Hao Zhang², Shuaiqi Li¹

¹School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.

Frontiers in Psychiatry

|October 14, 2024

Summary

Methamphetamine abuse significantly impairs sequential working memory, the ability to manage ordered information. Abstinent users struggled with tasks requiring this skill, unlike those relying solely on short-term memory.

Keywords:

cognitive deficits digit ordering task methamphetamine dependence sequential working memory working memory

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Area of Science:

Neuroscience
Cognitive Psychology
Addiction Research

Background:

Working memory is crucial for daily tasks.
Methamphetamine abuse is known to affect general working memory.
The specific impact on sequential working memory is not well understood.

Purpose of the Study:

To investigate the effect of methamphetamine abuse on sequential working memory.
To differentiate the impact on sequential versus short-term memory.

Main Methods:

A digit ordering task was administered to 62 abstinent methamphetamine-dependent participants and 59 controls.
Participants recalled and ordered digits presented sequentially.
Two conditions: random digit presentation (experimental) and ascending order (control).

Main Results:

Methamphetamine-dependent participants performed significantly worse in the experimental condition requiring sequential working memory.
Performance did not differ between groups in the control condition, which relied on short-term memory.

Conclusions:

Methamphetamine abuse demonstrably impairs sequential working memory.
The findings highlight a specific cognitive deficit associated with methamphetamine dependence.