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Oral Microbiota Variations in Psoriasis Patients Without Comorbidity
Kaidi Zhao1, Yang Zhao2, Ao Guo1
1Department of Dermatology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, People's Republic of China.
Clinical, Cosmetic and Investigational Dermatology
|October 14, 2024
Summary
Psoriasis patients show altered oral microbiota with higher diversity and specific bacteria like Prevotella. Certain oral microbes correlate with psoriasis severity, offering new insights into this skin condition.
Area of Science:
- Microbiome research
- Dermatology
- Oral health
Background:
- Psoriasis is a chronic inflammatory skin disease with unclear origins.
- Growing evidence links microorganisms to psoriasis triggers.
- The connection between psoriasis and oral microbiota is not well understood.
Purpose of the Study:
- Compare oral microbiota composition and diversity in psoriasis patients versus healthy controls.
- Identify oral microbial markers for assessing psoriasis severity.
Main Methods:
- Saliva samples from 20 psoriasis patients and 20 healthy controls.
- 16S rRNA sequencing for oral microbiome analysis.
- Statistical analyses including Shannon Index, PCoA, LEfSe, and correlation tests.
Main Results:
- Psoriasis patients exhibited higher oral microbiota alpha diversity.
- Increased relative abundance of Prevotella, Prevotella 7, and Porphyromonas gingivalis in psoriasis patients.
- Positive correlation of Alloprevotella, Porphyromonas, and Neisseria with psoriasis severity; negative correlation with Veillonella.
Conclusions:
- Significant alterations in oral microbiota composition are observed in psoriasis patients.
- Specific oral bacteria are associated with psoriasis severity.
- This study provides novel perspectives on the oral microbiota-psoriasis relationship.
