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Updated: Jun 10, 2025
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COVID-19-related Pneumonitis in Immunocompromised Patients: Reviewing Clinical Features and Management Approaches
Adeel Nasrullah1, Hassan Shakir2, Eiraj Khan3
1Division of Pulmonary and Critical Care Medicine, Allegheny Health Network, Pittsburgh, PA, 15212, USA.
Abstract:
In this case series, we explore persistent SARS-CoV-2 infection and its resultant pneumonitis within a cohort of immunocompromised patients. We elucidate the complex interplay between immunosuppression and COVID-19 by examining four patients who experienced prolonged viral shedding and recurrent respiratory failure due to their compromised immune systems. This series elucidates the clinical presentation, diagnostic challenges, and therapeutic strategies. We also summarize existing literature regarding persistent SARS-CoV-2 infection in immunocompromised individuals. Our findings support the use of a tailored treatment approach using a proposed diagnostic and management algorithm to standardize care and optimize outcomes.
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