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From patient classification to optimized treatment in ART: the AMPLITUDE Delphi consensus
Christophe Blockeel1, Anne Guivarc'h-Leveque2, Catherine Rongieres3
1Brussels IVF, Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Frontiers in Reproductive Health
|October 14, 2024
Summary
Expert consensus was reached on personalizing ovarian stimulation protocols for assisted reproductive technology. Key factors include initial gonadotropin dosing, fresh or frozen embryo transfer strategies, and optimal oocyte yield for improved patient outcomes.
Area of Science:
- Reproductive Endocrinology
- Assisted Reproductive Technology (ART)
Background:
- Ovarian stimulation protocols require optimization for personalized patient care in ART.
- Expert opinions vary on managing key aspects of ovarian stimulation, necessitating consensus-building.
Purpose of the Study:
- To establish a Delphi consensus among fertility specialists on optimizing ovarian stimulation protocols.
- To develop evidence-based recommendations for patient profiles based on predicted ovarian response.
Main Methods:
- A Scientific Committee developed eleven statements for patient profiles (low, normal, high responders).
- Statements were surveyed among French and Belgian fertility specialists using an online platform.
- Consensus was defined as agreement by ≥66.7% of participants.
Main Results:
- Consensus was achieved on personalizing initial gonadotropin dosage considering patient-specific factors.
- Preferences were established for fresh transfer (low/normal responders) versus freeze-all strategies (high responders/specific conditions).
- An optimal oocyte target of 10-15 was agreed upon, with strategies for adjusting gonadotropin dosage and selecting subsequent cycle protocols.
Conclusions:
- The AMPLITUDE consensus highlights the importance of tailored ovarian stimulation protocols in ART.
- These findings provide guidance for fertility specialists to enhance ovarian stimulation outcomes.
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