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Updated: Jun 10, 2025

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
Pd(II)-Catalyzed Chemo-, Diastereo-, and Enantioselective C(sp3)-H Arylation to Construct Contiguous Phosphorus and
Le-Song Wu1, Chen-Yue Wang1, Tao Zhou1,2
1Center of Chemistry for Frontier Technologies, Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Abstract:
Chiral phosphorus compounds with contiguous P,C-stereogenic centers are widely found in chiral ligands. The synthesis of these skeletons has been scarcely reported. Herein, we developed a Pd(II)-catalyzed chemo-, diastereo-, and enantioselective arylation of diisopropyl phosphinamide enabled by 2-pyridinylisopropyl (PIP) auxiliary and (S)-6,6'-(CN)2-SPINOL. A range of chiral phosphinamides containing contiguous P,C-stereocenters were obtained in good yields (up to 85%) with excellent enantioselectivities (up to >99% ee).
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