Personalized oncology, ethics and adherence to NCCN guidelines

Area of Science:

• Oncology
• Medical Ethics
• Clinical Decision-Making

Background:

• Personalized oncology leverages evidence-based information, notably the National Comprehensive Cancer Network (NCCN) Guidelines.
• Effective personalized care requires clinicians to present guideline information clearly and without bias to patients.
• Shared decision-making is crucial for aligning treatment with individual patient preferences, goals, and values.

Purpose of the Study:

• To discuss the ethical implications of deviating from NCCN Guidelines in personalized oncology.
• To explore the balance between established guidelines and individual patient needs in cancer care.

Main Methods:

• Ethical analysis of clinical decision-making in personalized oncology.
• Review of the role of NCCN Guidelines in contemporary cancer treatment.
• Discussion of shared decision-making processes between clinicians and patients.

Main Results:

• NCCN Guidelines are a cornerstone of modern personalized oncology.
• Patient comprehension and values are critical for successful shared decision-making.
• Deviating from NCCN Guidelines presents ethical challenges that require careful consideration.

Conclusions:

• Integrating NCCN Guidelines with patient-specific factors is essential for ethical personalized oncology.
• The ethical framework must support clinicians in navigating deviations from guidelines when necessary for patient-centered care.