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Related Experiment Videos

The small lentiginous nevus.

S Wolinsky1, D N Silvers

  • 1Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York.

The American Journal of Dermatopathology
|January 1, 1985
PubMed
Summary
This summary is machine-generated.

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Simple lentigines may actually be lentiginous nevi. Careful examination of serial sections revealed melanocyte nests in some lesions initially appearing as simple lentigines, suggesting a potential misclassification.

Area of Science:

  • Dermatopathology
  • Histopathology
  • Melanocytic Lesions

Background:

  • Lentiginous nevi are benign melanocytic proliferations.
  • Simple lentigines are characterized by increased melanocytes along the basal layer.
  • Distinguishing between lentigines and early lentiginous nevi can be challenging.

Purpose of the Study:

  • To investigate the histological features of small lentiginous nevi.
  • To determine if simple lentigines might represent early or under-diagnosed lentiginous nevi.

Main Methods:

  • Histopathological examination of 18 small lentiginous nevi (1-3 mm).
  • Inclusion of serial sectioning (100-125 sections) for detailed analysis.
  • Comparative diagnosis based on standard and serial section examination.

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Main Results:

  • Eighteen small lentiginous nevi exhibited melanocyte nests in the lower epidermis.
  • Six of these nevi (33%) showed melanocyte nests only after extensive serial sectioning.
  • Without serial sections, these six lesions would have been classified as simple lentigines.

Conclusions:

  • Simple lentigines may histologically represent lentiginous nevi.
  • Extensive serial sectioning is crucial for accurate diagnosis of small melanocytic lesions.
  • Re-evaluation of the classification of simple lentigines is warranted.