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Published on: November 9, 2018
A smartphone-assisted test paper fluorescence sensing platform for visual detection of α-Ketoglutaric acid based on
Jianhua Zhang1, Bao Qin1, Lijun Song1
1College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot 010051, China; Inner Mongolia Engineering Research Center for CO(2) Capture and Utilization, Hohhot 010051, China; Key Laboratory of CO(2) Resource Utilization at Universities of Inner Mongolia Autonomous Region, Hohhot 010051, China.
Abstract:
Developing an accurate, sensitive and visual strategy for quickly identifying biomarkers α-ketoglutaric acid (α-KA) is crucial for early disease diagnosis. Herein, we introduce a new fluorescence material, Eu3+@COMOC-4, synthesized by post-synthesis modification of a lanthanide-functionalized metal-organic frameworks (MOFs). This material serves as a visual fluorescence sensor to detect α-KA, with a distinct fluorescence response. Particularly, the sensor exhibits many advantages, such as good selectivity, high sensitivity and quick response. The quenching mechanism between the sensor and α-KA was also illustrated in detail. More significantly, a smartphone-integrated test paper fluorescence sensing platform was further developed for α-KA detection, which enables sensitive, real-time, and visual detection of α-KA. This work provides a sensitive and real-time biomarker detection strategy, which is expected to expand the application of MOFs in significant fields.
