Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 10, 2025

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates
08:41

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates

Published on: July 17, 2020

4.9K

Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.

Takafumi Minamimoto1, Yuji Nagai1, Kei Oyama1

  • 1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan.

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
|October 14, 2024
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy.

Science advances·2026
Same author

Remote Cortical Network for Frontal Cognitive Symptoms Derived from Tau Accumulation in Progressive Supranuclear Palsy.

bioRxiv : the preprint server for biology·2025
Same author

Longitudinal assessment of DREADD expression and efficacy in the monkey brain.

eLife·2025
Same author

Functional Heterogeneity within the Primate Ventral Striatum for Motivational Regulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Neural Correlates of Category Learning in Monkey Inferior Temporal Cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same author

Unsupervised decomposition of natural monkey behavior into a sequence of motion motifs.

Communications biology·2024

Designer receptors exclusively activated by designer drugs (DREADDs) enhance nonhuman primate research by enabling precise control and monitoring of neural circuits. This technology advances brain function studies and therapeutic development for neurological disorders.

Area of Science:

  • Neuroscience
  • Primate Research
  • Genetic Neuromodulation

Background:

  • Nonhuman primates (macaques, marmosets) are crucial models for brain function and behavior research.
  • Limited genetic neuromodulation tools have hindered network-level investigations in these models.
  • Need for precise methods to control and study neural circuits in primates.

Purpose of the Study:

  • To review the application of chemogenetic technology, specifically DREADDs, in nonhuman primates.
  • To highlight how DREADDs enable reversible control of neuronal activity in specific cell types or pathways.
  • To discuss the integration of DREADDs with advanced imaging techniques for enhanced primate brain research.

Main Methods:

  • Utilizing designer receptors exclusively activated by designer drugs (DREADDs) for chemogenetic neuromodulation.
Keywords:
DREADDmonkeyneuroimagingneuromodulationpositron emission tomography

More Related Videos

Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research
06:33

Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research

Published on: February 9, 2024

1.1K
Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

6.4K

Related Experiment Videos

Last Updated: Jun 10, 2025

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates
08:41

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates

Published on: July 17, 2020

4.9K
Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research
06:33

Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research

Published on: February 9, 2024

1.1K
Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

6.4K
  • Applying DREADDs to reversibly control neuronal activity in targeted cell types and neural pathways.
  • Combining DREADDs with imaging modalities like PET and MRI for visualization and monitoring.

    • Main Results:

    • DREADDs allow simultaneous targeting of multiple brain regions in nonhuman primates.
    • Integration with PET and MRI facilitates precise visualization and manipulation of brain circuits.
    • Enables detailed monitoring of network activity changes correlated with behavioral alterations.

    Conclusions:

    • DREADDs represent a significant technological advance for nonhuman primate neuroscience research.
    • This approach enhances the understanding of primate brain circuit function.
    • Potential for developing novel therapeutic strategies for brain diseases is increased.