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Optic neuritis in Rosai Dorfman disease
Swati Phuljhele1, Himani Thakur2, Rohit Saxena2
1Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India. drmsswati@rediffmail.com.
Eye (London, England)
|October 14, 2024
Summary
A 55-year-old man with unexplained weight loss was diagnosed with Rosai-Dorfman disease. This rare condition was identified through PET-CT scans showing active lymph nodes and subsequent biopsy results.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Investigating unexplained weight loss in a 55-year-old male.
- Evaluating patient for potential malignancy or systemic disease.
Observation:
- Positron emission tomography-computed tomography (PET-CT) revealed multiple metabolically active lymph nodes.
- Biopsy of a right axillary lymph node was performed for diagnostic purposes.
Findings:
- Histopathological examination showed numerous histiocytes exhibiting emperipolesis.
- Immunohistochemical staining was positive for S100 protein.
- These findings are characteristic of Rosai-Dorfman disease.
Implications:
- Rosai-Dorfman disease is a rare, benign histiocytic disorder.
- Accurate diagnosis is crucial for appropriate patient management.
- Further research into the pathogenesis and treatment of Rosai-Dorfman disease is warranted.
