"All-in-One" MnO₂@PtAuRu Nanoreactor for Self-Replenishing and Cascade Catalytic Therapy of Cancer

Limited by the insufficient catalytic substrates such as H₂O₂ and O₂ in the tumor microenvironment (TME), the continual propelling of nanozymes catalysis therapy of cancer remains a challenge. Here, an all-in-one MnO₂@PtAuRu nanoreactor is constructed for self-propelled and cascade catalytic therapy of tumors. The MnO₂@PtAuRu is constructed by using hollow MnO₂ (≈150 nm) as the core-carrier and ultrasmall PtAuRu nanoclusters (≈2 nm) anchoring on the surface MnO₂. According to the glucose oxidase (GOD)/catalase (CAT)/peroxidase (POD) mimic multienzyme activity of PtAuRu nanoclusters, cascaded nanocatalytic reactions can be self-replenishing to persistently produce •OH for superior chemodynamic therapy (CDT). Additionally, the MnO₂ carrier can protect the ultrasmall PtAuRu nanoclusters during the circulation and the overexpressed glutathione (GSH) in the tumor can also be degraded by the MnO₂ to synergy the CDT. The MnO₂@PtAuRu displays obvious photothermal properties which further enhance the cascade catalytic ability and synergistic therapeutic effect. Therefore, this all-in-one nanozyme provides a promising strategy for the rational design of self-replenishment and self-replenishing cascade catalytic therapy of cancer.