An insight into pharmacokinetics and dose optimization of antimicrobials agents in elderly patients
Guanshuang Fu1,2, Weijia Sun3, Zhaoyi Tan1
1Centre of Medicine Clinical Research, Department of Pharmacy, PLA General Hospital, Beijing, China.
Abstract:
The global elderly population is on the rise, and infections tend to have a higher mortality rate among older individuals. Aging is associated with the progressive impairment of multi-organ function, which can impact the pharmacokinetics of antimicrobials, potentially leading to the failure of anti-infective therapy. With the increasing life expectancy, a significant growth in the elderly demographic, and the escalating costs of healthcare, gaining a thorough understanding of pharmacokinetic changes in the elderly holds crucial clinical significance. This review compiles findings from published studies, offering a comprehensive overview of the pharmacokinetics of various antimicrobials in both adults and the elderly. Furthermore, it delves into advancements in pharmacokinetic methods specific to the elderly population.
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