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  1. Home
  3. Causal Effects Of Serum Calcium, Phosphate, And 25-hydroxyvitamin D On Kidney Function: A Genetic Correlation, Pleiotropic Analysis, And Mendelian Randomization Study.
  1. Home
  3. Causal Effects Of Serum Calcium, Phosphate, And 25-hydroxyvitamin D On Kidney Function: A Genetic Correlation, Pleiotropic Analysis, And Mendelian Randomization Study.

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Causal effects of serum calcium, phosphate, and 25-hydroxyvitamin D on kidney function: a genetic correlation,

Yanjun Liang1,2,3, Shuang Liang2, Dayang Xie1,2

  • 1Medical School of Chinese People's Liberation Army (PLA), Beijing, China.

Frontiers in Endocrinology
|October 15, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
25-hydroxyvitamin DMendelian randomizationcalciumgenetic correlationkidney functionparathyroid hormonephosphatepleiotropic analysis

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Elevated serum calcium or phosphate levels can impair kidney function, while 25-hydroxyvitamin D does not significantly affect renal function. This Mendelian randomization study clarifies the causal links between these biomarkers and kidney health.

Area of Science:

  • Genetics
  • Nephrology
  • Endocrinology

Background:

  • Inconsistent findings exist regarding the impact of serum calcium (Ca), phosphate (P), 25-hydroxyvitamin D (25[OH]D), and parathyroid hormone (PTH) on kidney function.
  • Establishing a direct causal relationship between these factors and kidney function requires further investigation.

Purpose of the Study:

  • To investigate the potential causal relationships between serum Ca, P, 25(OH)D, and kidney function using Mendelian randomization.
  • To clarify the impact of these key biomarkers on indicators of kidney function such as estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), and urine albumin-to-creatinine ratio (UACR).

Main Methods:

  • Utilized genome-wide association study datasets from UK Biobank and CKDGen Consortium.
  • Employed linkage disequilibrium score regression (LDSC) for heritability and genetic correlation analyses.
  • Conducted Mendelian randomization (MR) analysis with instrumental variables to assess causal effects.

    • Main Results:

    • Serum calcium (Ca) showed a positive association with urine albumin-to-creatinine ratio (UACR).
    • Serum phosphate (P) was associated with decreased eGFR and increased BUN.
    • Genetically predicted 25-hydroxyvitamin D (25[OH]D) did not demonstrate a significant impact on kidney function indicators.

    Conclusions:

    • Elevated serum calcium or phosphate levels may impair kidney function.
    • Serum phosphate's detrimental effect on kidney function was further supported by multivariable MR analysis.
    • 25-hydroxyvitamin D levels do not appear to have a significant causal impact on renal function.