Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Postoperative Complications and Long-Term Cardiovascular Risk After Gastrectomy for Gastric Cancer.

Annals of surgical oncology·2026

Same author

Cardiovascular Disease Risk Among Young Adults with Disabilities: A Nationwide Cohort Study.

European journal of preventive cardiology·2026

Same author

SFXN3 Serves as a Predictive Biomarker for Cisplatin Response and Survival in Head and Neck Squamous Cell Carcinoma.

Oncology research·2026

Same author

Residential green space and incidence of cardiovascular disease: Evidence from a nationwide population-based study.

International journal of hygiene and environmental health·2026

Same author

Genipin-crosslinked CeO<sub>2</sub>-incorporating Janus patch for oral ulcer treatment.

RSC advances·2026

Same author

SIGMA: Shear-induced gelation by microbead aggregation in tubular flow systems.

Materials today. Bio·2026

Search research articles

Related Experiment Video

Updated: Jun 10, 2025

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Synergistic effect of ROS-generating polydopamine on drug-induced bone tissue regeneration.

Hyeju Han^1,2, Bongkyun Kang², Shazid Md Sharker³

¹Department of Chemistry, Kyungpook National University, Daegu 41566, South Korea. kyueui@knu.ac.kr.

|October 15, 2024

Summary

This study developed a novel polydopamine (PDA) drug delivery system for 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA). This system significantly enhanced bone regeneration by over sixfold in mice.

More Related Videos

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Related Experiment Videos

Last Updated: Jun 10, 2025

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Area of Science:

Biomaterials Science
Regenerative Medicine
Drug Delivery Systems

Background:

Prolyl hydroxylase (PHD) inhibitors, like 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA), promote tissue regeneration by upregulating hypoxia-inducible factor 1 subunit alpha (Hif-1α).
Developing effective drug delivery systems is crucial for maximizing the therapeutic potential of regenerative agents.

Purpose of the Study:

To design a novel polydopamine (PDA)-based drug delivery system for 1,4-DPCA.
To investigate the synergistic effects of PDA-generated reactive oxygen species (ROS) and 1,4-DPCA on tissue regeneration.

Main Methods:

Encapsulation of 1,4-DPCA within PDA nanoparticles.
Evaluation of Hif-1α upregulation and cellular antioxidant defense mechanisms.
Assessment of bone regeneration in a mouse calvarial defect model.

Main Results:

The combined PDA and 1,4-DPCA system demonstrated a synergistic effect on regenerative mechanisms.
Localized ROS generation by PDA enhanced cellular antioxidant defenses.
A sixfold increase in bone regeneration was observed compared to the control group.

Conclusions:

PDA serves as an effective drug delivery vehicle for 1,4-DPCA, enhancing its regenerative properties.
The developed system offers a promising strategy for significantly improving bone tissue regeneration.