Related Experiment Video

Updated: Jun 10, 2025

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
11:32

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry

Published on: September 28, 2016

13.2K

Transient Receptor Potential Canonical Channels in Cardiovascular Pathology and Their Modulators

Hussein N Rubaiy1

  • 1Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden .

Journal of Cardiovascular Pharmacology
|October 15, 2024
PubMed

Insights

Transient Receptor Potential Canonical (TRPC) channels are vital for heart function and cardiovascular diseases. Understanding TRPC channel roles in cardiovascular pathology is key for developing new therapeutic strategies.

Area of Science:

  • Cardiovascular Physiology and Pathology
  • Molecular Biology
  • Ion Channel Function

Background:

  • Ion channels are critical for cardiac rhythm and contractility, making them therapeutic targets for cardiovascular diseases.
  • Calcium (Ca 2+ ) concentration and plasma membrane voltage significantly influence cell function, regulated by Ca 2+ -permeable nonselective cationic channels.
  • The Transient Receptor Potential (TRP) superfamily includes diverse Ca 2+ -permeable nonselective cation channels, with Canonical (TRPC) channels being ubiquitously expressed in mammalian cells.

Purpose of the Study:

  • To investigate the specific roles of TRPC channels within the cardiovascular system.
  • To provide a comprehensive discussion on the involvement of TRPC channels in cardiovascular pathology.
  • To highlight the importance of understanding TRPC channel molecular mechanisms and regulatory pathways for novel therapeutic development.

Main Methods:

  • Literature review focusing on TRPC channel function in cardiovascular physiology.
  • Analysis of existing research on TRPC channel involvement in cardiovascular diseases.
  • Exploration of molecular mechanisms and regulatory pathways of TRPC channels in cardiovascular conditions.

Main Results:

  • TRPC channels are integral to cardiovascular system function.
  • TRPC channels are implicated in various cardiovascular pathologies.
  • Detailed understanding of TRPC channel mechanisms is crucial for therapeutic advancements.

Conclusions:

  • TRPC channels are essential regulators of cardiovascular function and disease.
  • Further research into TRPC channel molecular biology and pathology is warranted.
  • Targeting TRPC channels holds promise for future cardiovascular disease treatments.

More Related Videos

Recording of Inward Rectifying K+ Currents in Freshly Isolated Basilar Artery Smooth Muscle Cells by Patch Clamp Technique07:19

Recording of Inward Rectifying K+ Currents in Freshly Isolated Basilar Artery Smooth Muscle Cells by Patch Clamp Technique

Published on: February 7, 2025

238
Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique08:11

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique

Published on: November 11, 2022

2.7K

Related Concept Videos

G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
4.5K
Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
468
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.3K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
8.0K
Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
462
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
6.7K