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A Multicenter Cohort Study on Ultrasound-based Deep Learning Nomogram for Predicting Post-Neoadjuvant Chemotherapy
Shuhan Sun1, Yajing Chen1, Yutong Liu1
1Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Rationale And Objectives:
The aim of this study was to evaluate the capability of an ultrasound (US)-based deep learning (DL) nomogram for predicting axillary lymph node (ALN) status after neoadjuvant chemotherapy (NAC) in breast cancer patients and its potential to assist radiologists in diagnosis.
Methods:
Two medical centers retrospectively recruited 535 node-positive breast cancer patients who had undergone NAC. Center 1 included 288 patients in the training cohort and 123 patients in the internal validation cohort, while center 2 enrolled 124 patients for the external validation cohort. Five DL models (ResNet 34, ResNet 50, VGG19, GoogLeNet, and DenseNet 121) were trained on pre- and post-NAC US images, and the best model was chosen. A US-based DL nomogram was constructed using DL predictive probabilities and clinicopathological characteristics. Furthermore, the performances of radiologists were compared with and without the assistance of the nomogram.
Result:
ResNet 50 performed best among all DL models, achieving areas under the curve (AUCs) of 0.837 and 0.850 in the internal and external validation cohorts, respectively. The US-based DL nomogram demonstrated strong predictive ability for ALN status post-NAC, with AUCs of 0.890 and 0.870 in the internal and external validation cohorts, respectively, outperforming both the clinical model and the DL model (p all < 0.05, except p = 0.19 for DL model in external validation cohort). Moreover, the nomogram significantly improved radiologists' diagnostic ability.
Conclusion:
The US-based DL nomogram is promising for predicting ALN status post-NAC and could assist radiologists for better diagnostic performance.
