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Curcumin-Based Molecularly Imprinted Polymer Electropolymerized on Single-Use Graphite Electrode for Dipyridamole

Daniel Preda1, Gabriel Lucian Radu2, Emilia-Elena Iorgulescu3

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Summary

A novel disposable electrochemical sensor was developed for dipyridamole (DIP) detection using curcumin and a molecularly imprinted polymer. This sensor offers sensitive and rapid quantification of DIP in pharmaceutical and tap water samples.

Keywords:
dipyridamoledisposable electrodeelectroanalysismodified electrodesmolecularly imprinted polymerpencil graphite electrode

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Area of Science:

  • Electrochemistry
  • Materials Science
  • Analytical Chemistry

Background:

  • Dipyridamole (DIP) is a medication with critical therapeutic applications.
  • Accurate and sensitive detection methods for DIP are essential for quality control and environmental monitoring.
  • Existing methods may lack the sensitivity, speed, or cost-effectiveness required for routine analysis.

Purpose of the Study:

  • To develop a novel, rapid, and cost-effective disposable electrochemical sensor for dipyridamole (DIP) determination.
  • To utilize molecularly imprinted polymer (MIP) technology combined with curcumin (CUR) as a functional monomer for enhanced sensor performance.
  • To validate the sensor's efficacy in quantifying DIP in real-world samples like pharmaceutical preparations and tap water.

Main Methods:

  • Fabrication of a molecularly imprinted polymer (MIP) on a pencil graphite electrode (PGE) via potentiodynamic electrochemical polymerization using curcumin (CUR) as a functional monomer and DIP as a template.
  • Optimization of polymerization conditions including pH, monomer-template ratio, scan rate, and cyclic voltammetric cycles.
  • Investigation of DIP voltammetric behavior at the MIP-modified electrode (MIP_PGE).
  • Quantification of DIP using differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV).

Main Results:

  • The MIP-based sensor demonstrated efficient and selective recognition of dipyridamole.
  • Optimized conditions yielded sensitive detection with linear ranges of 5.00 × 10-8-1.00 × 10-5 mol/L (DPV) and 5.00 × 10-9-1.00 × 10-7 mol/L (AdSDPV).
  • Achieved low limits of detection: 1.47 × 10-8 mol/L (DPV) and 3.96 × 10-9 mol/L (AdSDPV).
  • The sensor successfully quantified DIP in pharmaceutical and tap water samples.

Conclusions:

  • The developed MIP-based electrochemical sensor offers a promising tool for sensitive and selective dipyridamole determination.
  • The use of curcumin as a functional monomer and potentiodynamic polymerization provides a rapid and effective sensor fabrication method.
  • The sensor's applicability in real samples highlights its potential for practical analytical applications in quality control and environmental monitoring.