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Inclusion Complexation of Remdesivir with Cyclodextrins: A Comprehensive Review on Combating Coronavirus
Arumugam Anitha1, Rajaram Rajamohan2, Moorthiraman Murugan3
1PG and Research Department of Chemistry, Government Arts College, Chidambaram 608 102, Tamil Nadu, India.
Molecules (Basel, Switzerland)
|October 16, 2024
Summary
Cyclodextrin derivatives enhance drug delivery, particularly for remdesivir, by improving solubility and stability. These advanced cyclodextrin assemblies show promise for personalized nanomedicine and precision therapeutics.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmacology
Background:
- Cyclodextrin (CD) derivatives are valued for biocompatibility and functionalization potential.
- CDs offer unique inclusion capabilities for therapeutic agent encapsulation.
- Recent advancements focus on CD-based assemblies for improved drug delivery.
Purpose of the Study:
- To review recent progress in cyclodextrin-based assemblies for drug delivery.
- To highlight the specific application of these assemblies with remdesivir (RMD).
- To explore future directions in CD-based nanomedicine.
Main Methods:
- Discussion of CD materials and their self-assembly/supramolecular assembly properties.
- Analysis of strategies for constructing CD-based assemblies: physical encapsulation, covalent conjugation, and surface functionalization.
- Review of recent literature on CD-RMD assemblies.
Main Results:
- CD-based assemblies improve solubility, stability, and bioavailability of encapsulated drugs like RMD.
- Various construction strategies yield effective drug delivery systems.
- CD assemblies offer enhanced therapeutic activity and controlled release kinetics.
Conclusions:
- CD-based assemblies represent a significant advancement in drug delivery systems.
- Further development of novel CD derivatives and integration with nanomedicine/gene therapy is promising.
- These technologies hold potential for personalized medicine and precision therapeutics.
