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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

488
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
488

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Related Experiment Video

Updated: Jun 10, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

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Published on: June 9, 2023

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Neoadjuvant Treatment in Locally Advanced Thyroid Carcinoma.

Víctor Navas Moreno1,2, Fernando Sebastián Valles1,2, Marcos Lahera Vargas1,2

  • 1Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, 28028 Madrid, Spain.

Journal of Clinical Medicine
|October 16, 2024
PubMed
Summary

Locally advanced thyroid cancer presents significant challenges. Neoadjuvant therapy, using agents like tyrosine kinase inhibitors, offers a new curative approach for these complex tumors.

Keywords:
advanced thyroid cancerneoadjuvant treatmenttargeted therapiesthyroid cancerthyroidectomy

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Area of Science:

  • Oncology
  • Endocrinology
  • Surgical Oncology

Background:

  • Focus has shifted from overdiagnosis of early-stage thyroid cancer to managing locally advanced tumors.
  • Locally advanced thyroid cancers are infrequent but complex, often associated with poor prognoses.
  • Traditional treatments involved aggressive surgery or palliative care due to limited preoperative options.

Purpose of the Study:

  • To review current scientific evidence on neoadjuvant treatment for locally advanced thyroid cancer.
  • To explore the emerging role of neoadjuvant therapy in improving surgical outcomes.
  • To discuss the impact of new therapeutic strategies on managing complex thyroid malignancies.

Main Methods:

  • Narrative review of existing scientific literature.
  • Analysis of studies focusing on neoadjuvant therapies for advanced thyroid cancer.
  • Synthesis of evidence on tyrosine kinase inhibitors and tumor biology.

Main Results:

  • Neoadjuvant therapy is emerging as a viable curative-intent strategy.
  • Tyrosine kinase inhibitors show promise, particularly in radioactive iodine-refractory cases.
  • Improved understanding of tumor biology supports targeted neoadjuvant approaches.

Conclusions:

  • Neoadjuvant therapy represents a significant advancement in treating locally advanced thyroid cancer.
  • This approach offers potential for tumor reduction, enabling less radical surgery.
  • Further research into neoadjuvant strategies is crucial for optimizing patient outcomes.