Exergames and Immersive Virtual Reality as a Novel Therapy Approach in Multiple Sclerosis: Randomised Feasibility...

Area of Science:

• Neuroscience
• Rehabilitation Medicine
• Digital Health

Background:

• Multiple sclerosis (MS) is a chronic, inflammatory, neurodegenerative autoimmune disease impacting the central nervous system.
• MS leads to significant motor and non-motor impairments, necessitating effective physical therapy interventions.
• Current physical therapy for MS often faces challenges in engagement and accessibility.

Purpose of the Study:

• To evaluate the feasibility and safety of an immersive virtual reality (IVR) exergame program for people with MS (pwMS).
• To assess the impact of IVR-based physical therapy on functional capacities in pwMS.
• To explore patient experience and usability of the IVR intervention.

Main Methods:

• A randomized, single-blind clinical trial involving 18 participants with MS.
• Participants were assigned to an experimental group (EG) using the IVR exergame program (ExeRVIEM) twice weekly or a control group (CG).
• Feasibility, safety, usability, and functional outcomes (lower limb strength, mobility, fall risk) were assessed.

Main Results:

• The IVR intervention was found to be feasible and safe, with no adverse effects reported.
• High usability (System Usability Scale 90.31%) and positive post-game experiences were observed.
• Significant improvements were noted in the EG for lower limb strength (p=0.042), functional mobility, and reduced fall risk (p=0.009, p=0.003).

Conclusions:

• Immersive virtual reality exergames present a feasible and safe physical therapy option for people with MS.
• The IVR program demonstrated potential benefits for improving functional abilities and reducing fall risk.
• IVR technology is a promising tool for the rehabilitation of neurodegenerative conditions like MS, particularly in younger adults.