Peroxisome proliferators show tumor-promoting but no direct transforming activity in vitro

The chemically unrelated hypolipidemic drugs, tiadenol, niadenate, and clofibrate have been tested for carcinogenic and tumor-promoting potential in the C3H/10TI/2 C18 cell test system. None of these chemicals were carcinogenic, while both niadenate and clofibrate were active tumor promoters at micromolar concentrations. All 3 drugs induced the differentiation of C3H/10T1/2 C18 cells to adipocytes. This latter finding confirms previously observed effects of the tumor promoter TPA.