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Updated: Jun 10, 2025

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Gold Self-Relay Catalysis Enabling Regioselective Bicyclization toward [5]Azahelicenes
Yi-Ting Shen1, Yan Zhang1, Cheng-Long Ji1,2
1School of Chemistry & Materials Science and Analyzing and Test Center, Jiangsu Normal University, Xuzhou 221116, China.
Abstract:
A gold self-relay catalysis driving a double annulation cascade starting from soft electron-biased 1,2-di(o-aminoaryl)alkynes and aldehydes is reported, enabling regioselective access to produce a series of [5]azahelicenes depending on the substitution pattern in generally good yields under mild conditions. This protocol exploits and unifies the π- and σ-Lewis acid capability of gold catalysts, featuring high molecular convergence, broad substrate flexibility, and good functional group compatibility and regioselectivity.
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