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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Idiopathic multicentric Castleman disease.

Vipul Chaudhari1, Simran Jatin Thakkar2, Namita Padwal2

  • 1Department of Gastroenterology, Lokamanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.

Journal of Cancer Research and Therapeutics
|October 16, 2024
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Summary
This summary is machine-generated.

This case study highlights multicentric Castleman disease, a rare disorder, presenting with prolonged fever and enlarged lymph nodes. The condition mimicked other diseases, ultimately involving the testes and requiring orchidectomy.

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder with diverse clinical presentations.
  • The plasma cell variant (PC-MCD) is characterized by systemic inflammation and lymphadenopathy.

Observation:

  • An elderly male presented with chronic fever, weight loss, edema, and inguinal lymphadenopathy.
  • Investigations revealed anemia, leukopenia, elevated ESR, and hypergammaglobulinemia.
  • Abdominal ultrasound showed enlarged necrotic lymph nodes; testicular enlargement was noted.

Findings:

  • Excision biopsy confirmed plasma cell variant of multicentric Castleman disease.
  • Bilateral orchidectomy revealed hematocele, testicular atrophy, and secondary involvement by PC-MCD.

Implications:

  • This case underscores the importance of considering PC-MCD in elderly patients with unexplained systemic symptoms and lymphadenopathy.
  • The presentation highlights the potential for PC-MCD to mimic other conditions, including testicular neoplasms.
  • Accurate diagnosis and management are crucial for improving patient outcomes in this rare disease.