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Successful administration of cetuximab using dose escalation method: a case report
Shasha Li1, Yanjuan Zhang2, Jiandong Zha3
1Department of Clinical Oncology, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. liss7@hku-szh.org.
Introduction:
Cetuximab, used to treat head and neck squamous cell carcinoma and metastatic colorectal cancer, can cause severe infusion reactions.
Case Presentation:
We report an 87-year-old East Asian woman with stage IV ileocecal signet ring cell carcinoma who experienced severe allergic reactions to cetuximab despite pre-treatment. A dose escalation method, involving weekly incremental doses with comprehensive pre-treatment and close monitoring, was employed, successfully reducing allergic reactions and allowing safe administration.
Conclusion:
This approach demonstrates a viable alternative for patients with hypersensitivity to cetuximab, warranting further research for personalized treatment optimization.
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