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Updated: Jun 10, 2025

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Restless Leg Syndrome and Its Relation to Mirtazapine: A Case Report
Kafayat O Oyejide1, Michael Miller1
1University of Texas Medical Branch, Galveston, USA.
Abstract:
Major depressive disorder (MDD) and Restless legs syndrome (RLS) present complex clinical challenges, often coexisting and complicating treatment strategies. While the relationship between MDD and RLS remains somewhat elusive, emerging evidence suggests a potential interplay between antidepressant medications and the worsening of RLS symptoms. This case report illuminates an instance where mirtazapine, a tetracyclic antidepressant commonly used in MDD, precipitated a resurgence of RLS symptoms in a patient with a previously controlled presentation.
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